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Utilizing the GCRLE grant, Munakata and Namekawa will appear much more closely at how oocytes are genomically primed and saved for later on use. They'll investigate the job of a chromatin remodeler in oocyte survival and fertility.
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Namekawa believes that in human oocytes, alterations in these styles could disrupt the delicate choreography of genes currently being turned on and off at the appropriate times — leaving them unprepared check here for fertilization or advancement into healthful embryos. Improvements in chromatin structure as an oocyte ages may additionally impression the way that chromosomes segregate for the duration of mobile division.
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